Structured Summary
Abstract
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
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Synonyms
10 entry terms
- Blast Transformation
- Blastogenesis
- Lymphoblast Transformation
- Lymphocyte Stimulation
- Lymphocyte Transformation
- Transformation, Blast
- Transformation, Lymphoblast
- Transformation, Lymphocyte
- Activation, Lymphocyte
- Stimulation, Lymphocyte
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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Indexing Annotation
lymphocyte transformation test goes here but do not index under specific agent inducing transformation unless particularly discussed; do not use for neoplastic transformation of lymphocytes ( = CELL TRANSFORMATION, NEOPLASTIC) or viral transformation of lymphocytes ( = CELL TRANSFORMATION, VIRAL); blast transformation in chronic myelogenous leukemia does not go here: index BLAST CRISIS
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History Note
2003 (1969); for BLAST TRANSFORMATION use BLAST CRISIS 1987-1992
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Previous Indexing
- Lymphocytes/immunology (1966-1968)
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NLM Classification
QW 525.5.L9
AMA Style
References
- National Library of Medicine. Lymphocyte Activation. Medical Subject Headings (MeSH). 2026. Unique ID D008213. http://id.nlm.nih.gov/mesh/2026/D008213
- Lymphocyte Activation. In: Wikidata. https://www.wikidata.org/wiki/Q22295739