Chemicals and Drugs

Maturation-Promoting Factor

Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.

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Synonyms

9 entry terms
  • Histone H1 Kinase, Growth-Associated
  • Histone H1 Kinase, M-Phase-Specific
  • M Phase-Promoting Factor
  • Mitosis-Promoting Factor
  • Histone H1 Kinase, Growth Associated
  • Histone H1 Kinase, M Phase Specific
  • M Phase Promoting Factor
  • Maturation Promoting Factor
  • Mitosis Promoting Factor

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

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History Note

91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93

MeSH Record

Previous Indexing

  • Growth Substances (1979-1990)

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Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.646.500w.984w
  2. D12.776w.167.200w.580w
  3. D12.776w.476.563w.646.500w.984w

AMA Style

References

  1. National Library of Medicine. Maturation-Promoting Factor. Medical Subject Headings (MeSH). 2026. Unique ID D016200. http://id.nlm.nih.gov/mesh/2026/D016200
  2. Maturation-Promoting Factor. In: Wikipedia. https://en.wikipedia.org/wiki/Maturation_promoting_factor
  3. Maturation-Promoting Factor. In: Wikidata. https://www.wikidata.org/wiki/Q417889