Chemicals and Drugs

Mecamylamine

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Chemical Identity

Chemical Information

Molecular Formula
C11H21N
Molecular Weight
167.29 g/mol
CAS Registry No.
60-40-2
IUPAC Name
N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
InChIKey
IMYZQPCYWPFTAG-UHFFFAOYSA-N
SMILES
CC1(C2CCC(C2)C1(C)NC)C
MeSH Unique ID
D008464
Source
PubChem CID 4032

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.100.080.550.500w
  2. D04w.075.080.500.500w

AMA Style

References

  1. National Library of Medicine. Mecamylamine. Medical Subject Headings (MeSH). 2026. Unique ID D008464. http://id.nlm.nih.gov/mesh/2026/D008464
  2. Mecamylamine. In: Wikipedia. https://en.wikipedia.org/wiki/Mecamylamine
  3. Mecamylamine. In: Wikidata. https://www.wikidata.org/wiki/Q3332124
  4. Mecamylamine. In: PubChem Compound. CID 4032. https://pubchem.ncbi.nlm.nih.gov/compound/4032