Chemicals and Drugs

Mechanistic Target of Rapamycin Complex 2

A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.

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MeSH Record

Synonyms

6 entry terms
  • MTORC-2
  • TOR Complex 2
  • TORC2
  • Target of Rapamycin Complex 2
  • mTORC2
  • Complex 2, TOR

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (2013)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.356w
  2. D08.811w.913w.696w.620.682w.700w.931.750w
  3. D12.776w.476.563w.931.750w

AMA Style

References

  1. National Library of Medicine. Mechanistic Target of Rapamycin Complex 2. Medical Subject Headings (MeSH). 2026. Unique ID D000076225. http://id.nlm.nih.gov/mesh/2026/D000076225
  2. Mechanistic Target of Rapamycin Complex 2. In: Wikipedia. https://en.wikipedia.org/wiki/MTORC2
  3. Mechanistic Target of Rapamycin Complex 2. In: Wikidata. https://www.wikidata.org/wiki/Q14876061