Chemicals and Drugs

TOR Serine-Threonine Kinases

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

36 entry terms
  • FK506 Binding Protein 12-Rapamycin Associated Protein 1
  • FKBP12-Rapamycin Associated Protein
  • FKBP12-Rapamycin Complex-Associated Protein
  • Mammalian Target of Rapamycin
  • Mechanistic Target of Rapamycin Protein
  • RAFT-1 Protein
  • Rapamycin Target Protein
  • TOR Kinase
  • TOR Kinases
  • TOR Serine-Threonine Kinase
  • Target of Rapamycin Protein
  • Target of Rapamycin Proteins
  • mTOR Protein
  • mTOR Serine-Threonine Kinase
  • mTOR Serine-Threonine Kinases
  • FK506 Binding Protein 12 Rapamycin Associated Protein 1
  • FKBP12 Rapamycin Associated Protein
  • FKBP12 Rapamycin Complex Associated Protein
  • Kinase, TOR
  • Kinase, TOR Serine-Threonine
  • Kinase, mTOR Serine-Threonine
  • Kinases, TOR Serine-Threonine
  • Kinases, mTOR Serine-Threonine
  • Protein Target, Rapamycin
  • Protein, RAFT-1
  • Protein, mTOR
  • RAFT 1 Protein
  • Rapamycin Protein Target
  • Serine-Threonine Kinase, TOR
  • Serine-Threonine Kinase, mTOR
  • Serine-Threonine Kinases, TOR
  • Serine-Threonine Kinases, mTOR
  • TOR Serine Threonine Kinase
  • TOR Serine Threonine Kinases
  • mTOR Serine Threonine Kinase
  • mTOR Serine Threonine Kinases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2011

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.931
  2. D12.776w.476.563w.931

AMA Style

References

  1. National Library of Medicine. TOR Serine-Threonine Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D058570. http://id.nlm.nih.gov/mesh/2026/D058570
  2. TOR Serine-Threonine Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q24723029