Structured Summary
Abstract
Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
See Also
MeSH Record
Synonyms
17 entry terms
- BSC1 Transport Protein
- Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
- Kidney-Specific Na-K-Cl Symporter
- NKCC2 Cotransporter
- NKCC2 Protein
- SLC12A1 Cotransporter
- SLC12A1 Protein
- Solute Carrier Family 12, Member 1
- Cotransporter, NKCC2
- Cotransporter, SLC12A1
- Kidney Specific Na K Cl Symporter
- Na-K-Cl Symporter, Kidney-Specific
- Protein, BSC1 Transport
- Protein, NKCC2
- Protein, SLC12A1
- Symporter, Kidney-Specific Na-K-Cl
- Transport Protein, BSC1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2014
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Member 1 Solute Carrier Family 12. Medical Subject Headings (MeSH). 2026. Unique ID D064466. http://id.nlm.nih.gov/mesh/2026/D064466
- Member 1 Solute Carrier Family 12. In: Wikidata. https://www.wikidata.org/wiki/Q24781621