Chemicals and Drugs

Menogaril

A semisynthetic anthracycline with the amino sugar on the D ring. It displays broad-spectrum antineoplastic activity against a variety of tumors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A semisynthetic anthracycline with the amino sugar on the D ring. It displays broad-spectrum antineoplastic activity against a variety of tumors.

Chemical Identity

Chemical Information

Molecular Formula
C28H31NO10
Molecular Weight
541.5 g/mol
CAS Registry No.
71628-96-1
IUPAC Name
(1R,10R,12R,21R,22S,23R,24R)-23-(dimethylamino)-4,8,12,22,24-pentahydroxy-10-methoxy-1,12-dimethyl-20,25-dioxahexacyclo[19.3.1.02,19.05,18.07,16.09,14]pentacosa-2,4,7(16),8,14,18-hexaene-6,17-dione
InChIKey
LWYJUZBXGAFFLP-OCNCTQISSA-N
SMILES
C[C@@]1(C[C@H](C2=C(C3=C(C=C2C1)C(=O)C4=C5C(=CC(=C4C3=O)O)[C@@]6([C@@H]([C@H]([C@@H]([C@H](O5)O6)O)N(C)C)O)C)O)OC)O
MeSH Unique ID
D017290
Source
PubChem CID 5288818

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

15 entry terms
  • 7-O-Methylnogarol
  • 7-OMEN
  • 7-con-O-Methylnogarol
  • Menogarol
  • Menogaril, (11 beta)-Isomer
  • Menogaril, (13 beta)-Isomer
  • Menogaril, (5 alpha)-Isomer
  • Menogaril, (5 alpha,11 beta)-Isomer
  • NSC-269148
  • TUT-7
  • Tomosar
  • NSC 269148
  • NSC269148
  • TUT 7
  • TUT7

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was 7-O-METHYLNOGAROL (NM) 1979-92

MeSH Record

Previous Indexing

  • Nogalamycin/analogs & derivatives (1979-1992)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.562.050.200w.650w.500w
  2. D04w.615w.562.050.200w.650w.500w
  3. D09w.408w.051.059.200w.650w.500w

AMA Style

References

  1. National Library of Medicine. Menogaril. Medical Subject Headings (MeSH). 2026. Unique ID D017290. http://id.nlm.nih.gov/mesh/2026/D017290
  2. Menogaril. In: Wikipedia. https://en.wikipedia.org/wiki/Menogaril
  3. Menogaril. In: Wikidata. https://www.wikidata.org/wiki/Q6817231
  4. Menogaril. In: PubChem Compound. CID 5288818. https://pubchem.ncbi.nlm.nih.gov/compound/5288818