Chemicals and Drugs

Mercaptopurine

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Chemical Identity

Chemical Information

Molecular Formula
C5H4N4S
Molecular Weight
152.18 g/mol
CAS Registry No.
50-44-2
IUPAC Name
3,7-dihydropurine-6-thione
InChIKey
GLVAUDGFNGKCSF-UHFFFAOYSA-N
SMILES
C1=NC2=C(N1)C(=S)N=CN2
MeSH Unique ID
D015122
Source
PubChem CID 667490

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

19 entry terms
  • 1,7-Dihydro-6H-purine-6-thione
  • 6-Mercaptopurine
  • 6-Mercaptopurine Monohydrate
  • 6-Thiohypoxanthine
  • 6-Thiopurine
  • 6H-Purine-6-thione, 1,7-dihydro-
  • 6 Mercaptopurine
  • 6 Mercaptopurine Monohydrate
  • 6 Thiohypoxanthine
  • 6 Thiopurine
  • BW 57-323H
  • Leupurin
  • Mecaptopurine Anhydrous
  • Mercaptopurina Wellcome
  • Puri-Nethol
  • Purimethol
  • Purinethol
  • BW 57 323H
  • BW 57323H

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2018(1985)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.489w.534w
  2. D03w.633.100.759.570w

AMA Style

References

  1. National Library of Medicine. Mercaptopurine. Medical Subject Headings (MeSH). 2026. Unique ID D015122. http://id.nlm.nih.gov/mesh/2026/D015122
  2. Mercaptopurine. In: Wikipedia. https://en.wikipedia.org/wiki/Mercaptopurine
  3. Mercaptopurine. In: Wikidata. https://www.wikidata.org/wiki/Q418529
  4. Mercaptopurine. In: PubChem Compound. CID 667490. https://pubchem.ncbi.nlm.nih.gov/compound/667490