Chemicals and Drugs

Mitomycin

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.

Chemical Identity

Chemical Information

Molecular Formula
C15H18N4O5
Molecular Weight
334.33 g/mol
CAS Registry No.
50-07-7
IUPAC Name
[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
InChIKey
NWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
MeSH Unique ID
D016685
Source
PubChem CID 5746

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • Mitomycin C
  • Mitomycin-C
  • Ametycine
  • Mitocin-C
  • Mutamycin
  • NSC-26980
  • Mitocin C
  • MitocinC
  • NSC 26980
  • NSC26980

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

MITOMYCINS is also available

MeSH Record

History Note

2000(1992); for MITOMYCIN use MITOMYCIN (NM) 1981-1991

MeSH Record

Previous Indexing

  • Mitomycins (1966-1991)

MeSH Hierarchy

Tree Numbers

  1. D02w.806w.400w.249w.350w
  2. D03w.383.097.500w.350w
  3. D03w.633.100.473.412w.249w.350w

AMA Style

References

  1. National Library of Medicine. Mitomycin. Medical Subject Headings (MeSH). 2026. Unique ID D016685. http://id.nlm.nih.gov/mesh/2026/D016685
  2. Mitomycin. In: Wikipedia. https://en.wikipedia.org/wiki/Mitomycin_C
  3. Mitomycin. In: Wikidata. https://www.wikidata.org/wiki/Q19856779
  4. Mitomycin. In: PubChem Compound. CID 5746. https://pubchem.ncbi.nlm.nih.gov/compound/5746