Chemicals and Drugs

Monensin

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.

Chemical Identity

Chemical Information

Molecular Formula
C36H62O11
Molecular Weight
670.9 g/mol
CAS Registry No.
17090-79-8
IUPAC Name
(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-ethyl-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoic acid
InChIKey
GAOZTHIDHYLHMS-KEOBGNEYSA-N
SMILES
CC[C@]1(CC[C@@H](O1)[C@@]2(CC[C@@]3(O2)C[C@@H]([C@H]([C@H](O3)[C@@H](C)[C@H]([C@H](C)C(=O)O)OC)C)O)C)[C@H]4[C@H](C[C@@H](O4)[C@@H]5[C@H](C[C@H]([C@@](O5)(CO)O)C)C)C
MeSH Unique ID
D008985
Source
PubChem CID 441145

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Coban
  • Monensin Monosodium Salt
  • Monensin Sodium
  • Monensin-A-Sodium Complex
  • Rumensin
  • Monensin A Sodium Complex

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87(75); was see under FURANS 1975-86

MeSH Record

Previous Indexing

  • Antibiotics (1972-1974)
  • Furans (1974)
  • Pyrans (1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.355w.291.933.500w
  2. D02w.540w.576w.625.500w
  3. D03w.383.312.600w
  4. D04w.345w.241.654.500w
  5. D04w.345w.674w.625.500w

AMA Style

References

  1. National Library of Medicine. Monensin. Medical Subject Headings (MeSH). 2026. Unique ID D008985. http://id.nlm.nih.gov/mesh/2026/D008985
  2. Monensin. In: Wikipedia. https://en.wikipedia.org/wiki/Monensin
  3. Monensin. In: Wikidata. https://www.wikidata.org/wiki/Q3493048
  4. Monensin. In: PubChem Compound. CID 441145. https://pubchem.ncbi.nlm.nih.gov/compound/441145