Structured Summary
Abstract
Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
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Synonyms
4 entry terms
- Marine Ladder Polyethers
- Polyether Antibiotics
- Polyether Ionophore Antibiotics
- Polyether Ionophores
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Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2024
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References
- National Library of Medicine. Polyether Polyketides. Medical Subject Headings (MeSH). 2026. Unique ID D000095662. http://id.nlm.nih.gov/mesh/2026/D000095662
- Polyether Polyketides. In: Wikidata. https://www.wikidata.org/wiki/Q107605772