Chemicals and Drugs

Nigericin

A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)

Chemical Identity

Chemical Information

Molecular Formula
C40H68O11
Molecular Weight
725.0 g/mol
CAS Registry No.
28380-24-7
IUPAC Name
(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid
InChIKey
DANUORFCFTYTSZ-SJSJOXFOSA-N
SMILES
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
MeSH Unique ID
D009550
Source
PubChem CID 34230

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

2 entry terms
  • Epinigericin
  • Pandavir

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under ANTIBIOTICS 1975-90

MeSH Record

Previous Indexing

  • Antibiotics (1969-1974)
  • Carboxylic Acids (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.355w.291.933.750w
  2. D02w.540w.576w.625.750w
  3. D03w.383.312.634w
  4. D03w.383.663.620w
  5. D04w.345w.241.654.750w
  6. D04w.345w.674w.625.750w

AMA Style

References

  1. National Library of Medicine. Nigericin. Medical Subject Headings (MeSH). 2026. Unique ID D009550. http://id.nlm.nih.gov/mesh/2026/D009550
  2. Nigericin. In: Wikipedia. https://en.wikipedia.org/wiki/Nigericin
  3. Nigericin. In: Wikidata. https://www.wikidata.org/wiki/Q7033077
  4. Nigericin. In: PubChem Compound. CID 34230. https://pubchem.ncbi.nlm.nih.gov/compound/34230