Diseases

Multiple Endocrine Neoplasia Type 2b

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.

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Classification

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MeSH Record

Synonyms

19 entry terms
  • MEA 2b
  • MEA IIb
  • MEN 2b
  • MEN 3
  • MEN III
  • MEN IIb
  • MEN2b
  • Mucosal Neuroma Syndrome
  • Multiple Endocrine Neoplasia, Type 2b
  • Multiple Endocrine Neoplasia, Type IIb
  • Multiple Endocrine Neoplasms Type 2b
  • Neoplasia, Multiple Endocrine Type 2b
  • Neoplasms, Multiple Endocrine Type 2b
  • Neuromata, Mucosal, With Endocrine Tumors
  • Wagenmann-Froboese Syndrome
  • Mucosal Neuroma Syndromes
  • Neuroma Syndrome, Mucosal
  • Syndrome, Wagenmann-Froboese
  • Wagenmann Froboese Syndrome

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent

MeSH Record

History Note

1995; MEA III & MEN III see NEOPLASMS, MULTIPLE ENDOCRINE 1983-1994

MeSH Record

Previous Indexing

  • Multiple Endocrine Neoplasia (1975-1994)

MeSH Hierarchy

Tree Numbers

  1. C04w.588.322w.400w.510w
  2. C04w.651.600w.510w
  3. C04w.700w.630w.510w
  4. C16w.320w.700w.630w.510w
  5. C19w.344w.400w.510w

AMA Style

References

  1. National Library of Medicine. Multiple Endocrine Neoplasia Type 2b. Medical Subject Headings (MeSH). 2026. Unique ID D018814. http://id.nlm.nih.gov/mesh/2026/D018814
  2. Multiple Endocrine Neoplasia Type 2b. In: Wikipedia. https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2B
  3. Multiple Endocrine Neoplasia Type 2b. In: Wikidata. https://www.wikidata.org/wiki/Q624748