Chemicals and Drugs

MutL Protein Homolog 1

Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • COCA2 Protein
  • Colon Cancer, Nonpolyposis Type 2 Protein
  • MLH1 Protein
  • MutL Homolog 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (1994-2016)
  • Nuclear Proteins (1995-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.074.766.500
  2. D08.811w.277w.040w.025w.215.500
  3. D12.776w.260w.540.500

AMA Style

References

  1. National Library of Medicine. MutL Protein Homolog 1. Medical Subject Headings (MeSH). 2026. Unique ID D000070957. http://id.nlm.nih.gov/mesh/2026/D000070957
  2. MutL Protein Homolog 1. In: Wikidata. https://www.wikidata.org/wiki/Q6716597