Chemicals and Drugs

MutL Proteins

DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.

MeSH Record

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MeSH Record

Synonyms

1 entry terms
  • MutL Homologs

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Adenosine Triphosphatases (1992-2016)
  • DNA Repair (1982-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.074.766
  2. D08.811w.277w.040w.025w.215
  3. D12.776w.260w.540

AMA Style

References

  1. National Library of Medicine. MutL Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000070956. http://id.nlm.nih.gov/mesh/2026/D000070956
  2. MutL Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q24723571