Chemicals and Drugs

NAD-Dependent Hydroxymethylglutaryl-CoA Reductases

Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes performs a catabolic role in microorganisms such as Pseudomonas mevalonii where it oxidatively acetylates MEVALONIC ACID to form 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A and NADH.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes performs a catabolic role in microorganisms such as Pseudomonas mevalonii where it oxidatively acetylates MEVALONIC ACID to form 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A and NADH.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

10 entry terms
  • 3-Hydroxy-3-methylglutaryl CoA-Reductase, NAD-Dependent
  • HMG CoA Reductase, NAD-Dependent
  • HMG CoA Reductases, NAD-Dependent
  • Hydroxymethylglutaryl CoA Reductase, NAD-Dependent
  • Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent
  • CoA-Reductase, NAD-Dependent 3-Hydroxy-3-methylglutaryl
  • HMG CoA Reductase, NAD Dependent
  • HMG CoA Reductases, NAD Dependent
  • Hydroxymethylglutaryl CoA Reductase, NAD Dependent
  • NAD-Dependent 3-Hydroxy-3-methylglutaryl CoA-Reductase

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with HYDROXYMETHYLGLUTARYL-COA-REDUCTASES, NADP-DEPENDENT

MeSH Record

History Note

2002

MeSH Record

Previous Indexing

  • Hydroxymethylglutaryl CoA Reductases (1989-2001)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.047w.820.150w.415.250w

AMA Style

References

  1. National Library of Medicine. NAD-Dependent Hydroxymethylglutaryl-CoA Reductases. Medical Subject Headings (MeSH). 2026. Unique ID D025781. http://id.nlm.nih.gov/mesh/2026/D025781
  2. NAD-Dependent Hydroxymethylglutaryl-CoA Reductases. In: Wikipedia. https://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase
  3. NAD-Dependent Hydroxymethylglutaryl-CoA Reductases. In: Wikidata. https://www.wikidata.org/wiki/Q2989497