Structured Summary
Abstract
A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
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Classification
Broader headings
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Synonyms
13 entry terms
- Type 1 Voltage-Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 1
- NAV1.1 Voltage Gated Sodium Channel
- Type 1 Voltage Gated Sodium Channel
- Voltage Gated Sodium Channel Type 1
- NAV1.1 alpha Subunit
- SCN1A Sodium Channel alpha Subunit
- Sodium Channel, Voltage-Gated, Type I, alpha Protein
- Voltage-Gated Sodium Channel Type 1 Subunit alpha
- Voltage-Gated Sodium Channel Type 1 alpha Subunit
- Voltage Gated Sodium Channel Type 1 Subunit alpha
- Voltage Gated Sodium Channel Type 1 alpha Subunit
- alpha Subunit, NAV1.1
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2013
MeSH Record
Previous Indexing
- Sodium Channels (1989-2012)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. NAV1.1 Voltage-Gated Sodium Channel. Medical Subject Headings (MeSH). 2026. Unique ID D062550. http://id.nlm.nih.gov/mesh/2026/D062550
- NAV1.1 Voltage-Gated Sodium Channel. In: Wikidata. https://www.wikidata.org/wiki/Q21126314