Chemicals and Drugs

Neurofilament Proteins

Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)

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Synonyms

9 entry terms
  • Neurofilament Protein
  • Protein, Neurofilament
  • Proteins, Neurofilament
  • Heavy Neurofilament Protein
  • Neurofilament Triplet Proteins
  • Neurofilament Protein, Heavy
  • Protein, Heavy Neurofilament
  • Proteins, Neurofilament Triplet
  • Triplet Proteins, Neurofilament

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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Indexing Annotation

/biosyn /physiol permitted

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History Note

92; was NEUROFILAMENT PROTEINS (NM) 1977-91

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Previous Indexing

  • Intermediate Filament Proteins (1982-1991)
  • Nerve Tissue Proteins (1970-1982)

MeSH Hierarchy

Tree Numbers

  1. D05.750w.078w.593.630
  2. D12.776w.220.475.630
  3. D12.776w.631w.630

AMA Style

References

  1. National Library of Medicine. Neurofilament Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D016900. http://id.nlm.nih.gov/mesh/2026/D016900
  2. Neurofilament Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q66563117