Chemicals and Drugs

Neurokinin B

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.

Chemical Identity

Chemical Information

Molecular Formula
C55H79N13O14S2
Molecular Weight
1210.4 g/mol
CAS Registry No.
86933-75-7
IUPAC Name
(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
InChIKey
NHXYSAFTNPANFK-HDMCBQFHSA-N
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC3=CN=CN3)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)N
MeSH Unique ID
D015287
Source
PubChem CID 5311312

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • Neurokinin beta
  • Neuromedin K

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2003 (1989)

MeSH Record

Previous Indexing

  • Kinins (1983-1988)
  • Neuropeptides (1987-1988)
  • Oligopeptides (1983-1986)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.812w.900w.550w
  2. D12.644w.400w.800w.550w
  3. D12.644w.456w.800w.550w
  4. D12.776w.467.812w.900w.550w
  5. D12.776w.631w.650w.800w.550w
  6. D23.469.050w.375w.850w.570w
  7. D23.529.812w.900w.550w

AMA Style

References

  1. National Library of Medicine. Neurokinin B. Medical Subject Headings (MeSH). 2026. Unique ID D015287. http://id.nlm.nih.gov/mesh/2026/D015287
  2. Neurokinin B. In: Wikipedia. https://en.wikipedia.org/wiki/Neurokinin_B
  3. Neurokinin B. In: Wikidata. https://www.wikidata.org/wiki/Q412604
  4. Neurokinin B. In: PubChem Compound. CID 5311312. https://pubchem.ncbi.nlm.nih.gov/compound/5311312