Chemicals and Drugs

Niemann-Pick C1 Protein

A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • NPC1 Protein
  • Niemann Pick C1 Protein

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2019

MeSH Record

Previous Indexing

  • Carrier Proteins (1997-2018)
  • Membrane Glycoproteins (1997-2018)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.594
  2. D12.776w.543w.585w.594
  3. D12.776w.543w.750w.058.250
  4. D12.776w.543w.750w.830.235
  5. D12.776w.624.776.633.250

AMA Style

References

  1. National Library of Medicine. Niemann-Pick C1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000077296. http://id.nlm.nih.gov/mesh/2026/D000077296
  2. Niemann-Pick C1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q69380784