Structured Summary
Abstract
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
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Synonyms
9 entry terms
- PEP PTPase
- PEP Protein Tyrosine Phosphatase
- PEST-Enriched Phosphatase
- PTP-PEST
- Protein Tyrosine Phosphatase, Non-Receptor Type 12
- PEST Enriched Phosphatase
- PTPase, PEP
- Phosphatase, PEST-Enriched
- Protein Tyrosine Phosphatase, Non Receptor Type 12
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008(1994)
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AMA Style
References
- National Library of Medicine. Non-Receptor Type 12 Protein Tyrosine Phosphatase. Medical Subject Headings (MeSH). 2026. Unique ID D054594. http://id.nlm.nih.gov/mesh/2026/D054594
- Non-Receptor Type 12 Protein Tyrosine Phosphatase. In: Wikidata. https://www.wikidata.org/wiki/Q24784628