Chemicals and Drugs

Notch Receptors

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

MeSH Record

Classification

Broader headings

Narrower headings

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MeSH Record

Synonyms

6 entry terms
  • Notch Protein
  • Notch Proteins
  • Notch Receptor
  • Receptors, Notch
  • Protein, Notch
  • Receptor, Notch

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2006(1990)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.725
  2. D12.776w.930w.770

AMA Style

References

  1. National Library of Medicine. Notch Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D051880. http://id.nlm.nih.gov/mesh/2026/D051880
  2. Notch Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q58675077