Structured Summary
Abstract
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
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Synonyms
7 entry terms
- Oligonucleotide Probe
- Probe, Oligonucleotide
- Probes, Oligonucleotide
- Oligodeoxyribonucleotide Probes
- Oligoribonucleotide Probes
- Probes, Oligodeoxyribonucleotide
- Probes, Oligoribonucleotide
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Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
89
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Previous Indexing
- Nucleic Acid Hybridization (1972-1988)
- Oligonucleotides (1972-1988)
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References
- National Library of Medicine. Oligonucleotide Probes. Medical Subject Headings (MeSH). 2026. Unique ID D015345. http://id.nlm.nih.gov/mesh/2026/D015345
- Oligonucleotide Probes. In: Wikidata. https://www.wikidata.org/wiki/Q50573424