Structured Summary
Abstract
An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.
Chemical Identity
Chemical Information
- Molecular Formula
- C21H23N3O2
- Molecular Weight
- 349.4 g/mol
- CAS Registry No.
- 404950-80-7
- IUPAC Name
- (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
- InChIKey
- FPOHNWQLNRZRFC-ZHACJKMWSA-N
- SMILES
- CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
- MeSH Unique ID
- D000077767
- Source
- PubChem CID 6918837
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- Farydak
- LBH 589
- LBH589
- NVP-LBH589
- NVP LBH589
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (2005)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Panobinostat. Medical Subject Headings (MeSH). 2026. Unique ID D000077767. http://id.nlm.nih.gov/mesh/2026/D000077767
- Panobinostat. In: Wikipedia. https://en.wikipedia.org/wiki/Panobinostat
- Panobinostat. In: Wikidata. https://www.wikidata.org/wiki/Q7131441
- Panobinostat. In: PubChem Compound. CID 6918837. https://pubchem.ncbi.nlm.nih.gov/compound/6918837