Chemicals and Drugs

Pemetrexed

A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • MTA
  • N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
  • Alimta
  • LY 231,514
  • LY 231514
  • LY-231,514
  • LY-231514
  • LY231514
  • Pemetrexed Disodium
  • 231,514, LY
  • 231514, LY
  • Disodium, Pemetrexed

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1994)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.100.759.758w.399.454w.650w
  2. D12.125w.067.625.525w
  3. D12.125w.119.409.525w

AMA Style

References

  1. National Library of Medicine. Pemetrexed. Medical Subject Headings (MeSH). 2026. Unique ID D000068437. http://id.nlm.nih.gov/mesh/2026/D000068437
  2. Pemetrexed. In: Wikipedia. https://en.wikipedia.org/wiki/Pemetrexed
  3. Pemetrexed. In: Wikidata. https://www.wikidata.org/wiki/Q415220