Structured Summary
Abstract
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Chemical Identity
Chemical Information
- Molecular Formula
- C11H16N4O4
- Molecular Weight
- 268.27 g/mol
- CAS Registry No.
- 53910-25-1
- IUPAC Name
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
- InChIKey
- FPVKHBSQESCIEP-JQCXWYLXSA-N
- SMILES
- C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
- MeSH Unique ID
- D015649
- Source
- PubChem CID 439693
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
12 entry terms
- 2'-Deoxycoformycin
- CI-825
- Co-Vidarabine
- Deoxycoformycin
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
- NSC-218321
- Nipent
- 2' Deoxycoformycin
- CI 825
- CI825
- NSC 218321
- NSC218321
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
1997 (1990); for CO-VIDARABINE use PENTOSTATIN 1982-1997
MeSH Record
Previous Indexing
- Azepines (1966-1978)
- Coformycin/analogs & derivatives (1979-1989)
- Deoxyribonucleosides (1971-1978)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Pentostatin. Medical Subject Headings (MeSH). 2026. Unique ID D015649. http://id.nlm.nih.gov/mesh/2026/D015649
- Pentostatin. In: Wikipedia. https://en.wikipedia.org/wiki/Pentostatin
- Pentostatin. In: Wikidata. https://www.wikidata.org/wiki/Q425470
- Pentostatin. In: PubChem Compound. CID 439693. https://pubchem.ncbi.nlm.nih.gov/compound/439693