Structured Summary
Abstract
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
Chemical Identity
Chemical Information
- Molecular Formula
- C11H16N4O5
- Molecular Weight
- 284.27 g/mol
- CAS Registry No.
- 11033-22-0
- IUPAC Name
- (2R,3R,4S,5R)-2-[(8R)-8-hydroxy-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-3-yl]-5-(hydroxymethyl)oxolane-3,4-diol
- InChIKey
- YOOVTUPUBVHMPG-LODYRLCVSA-N
- SMILES
- C1[C@H](C2=C(NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)O
- MeSH Unique ID
- D003070
- Source
- PubChem CID 25447
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Aspects Covered
26 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
an enzyme inhib & antineoplastic antibiotic
MeSH Record
History Note
90(79); was see under RIBONUCLEOSIDES 1979-89
MeSH Record
Previous Indexing
- Azepines (1966-1978)
- Nucleosides (1966-1970)
- Ribonucleosides (1971-1978)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Coformycin. Medical Subject Headings (MeSH). 2026. Unique ID D003070. http://id.nlm.nih.gov/mesh/2026/D003070
- Coformycin. In: Wikidata. https://www.wikidata.org/wiki/Q27098587
- Coformycin. In: PubChem Compound. CID 25447. https://pubchem.ncbi.nlm.nih.gov/compound/25447