Chemicals and Drugs

Peroxisomal Bifunctional Enzyme

A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

19 entry terms
  • 2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase
  • Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase
  • L-Bifunctional Enzyme
  • L-Peroxisomal Bifunctional Enzyme
  • Peroxisomal Hydratase-Dehydrogenase-Epimerase
  • Peroxisomal Multifunctional beta-Oxidation Protein
  • Peroxisomal Trifunctional Enzyme
  • Peroxisomal-Bifunctional Enzymes
  • Bifunctional Enzyme, L-Peroxisomal
  • Bifunctional Enzyme, Peroxisomal
  • Dehydrogenase, Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA
  • Enoyl CoA Hydratase 3 Hydroxyacyl CoA Dehydrogenase
  • Hydratase-3-Hydroxyacyl-CoA Dehydrogenase, Enoyl-CoA
  • Hydratase-Dehydrogenase-Epimerase, Peroxisomal
  • L Bifunctional Enzyme
  • L Peroxisomal Bifunctional Enzyme
  • Peroxisomal Bifunctional Enzymes
  • Peroxisomal Hydratase Dehydrogenase Epimerase
  • Peroxisomal Multifunctional beta Oxidation Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Hierarchy

Tree Numbers

  1. D08.811w.399w.475.400.349w.500
  2. D08.811w.520w.241.300w.250w.750
  3. D08.811w.641.781
  4. D08.811w.682w.047w.820.150w.207.500

AMA Style

References

  1. National Library of Medicine. Peroxisomal Bifunctional Enzyme. Medical Subject Headings (MeSH). 2026. Unique ID D063994. http://id.nlm.nih.gov/mesh/2026/D063994
  2. Peroxisomal Bifunctional Enzyme. In: Wikidata. https://www.wikidata.org/wiki/Q73617792