Chemicals and Drugs

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

6 entry terms
  • PGC-1-alpha Protein
  • PPARGC-1-alpha Protein
  • PPARGC1a Protein
  • PGC 1 alpha Protein
  • PPARGC 1 alpha Protein
  • Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 alpha

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Transcription Factors (2004-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.314.650
  2. D12.776w.157w.057w.080.650
  3. D12.776w.157w.725w.813.875
  4. D12.776w.476.024w.394.650
  5. D12.776w.660w.675.650
  6. D12.776w.664w.962w.813.875
  7. D12.776w.930w.617.650

AMA Style

References

  1. National Library of Medicine. Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha. Medical Subject Headings (MeSH). 2026. Unique ID D000071248. http://id.nlm.nih.gov/mesh/2026/D000071248
  2. Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha. In: Wikidata. https://www.wikidata.org/wiki/Q29564764