Chemicals and Drugs

Nuclear Receptor Coactivators

Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.

MeSH Record

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MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Transcription Factors (1991-2009)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.314
  2. D12.776w.157w.057w.080
  3. D12.776w.476.024w.394
  4. D12.776w.660w.675
  5. D12.776w.930w.617

AMA Style

References

  1. National Library of Medicine. Nuclear Receptor Coactivators. Medical Subject Headings (MeSH). 2026. Unique ID D056918. http://id.nlm.nih.gov/mesh/2026/D056918
  2. Nuclear Receptor Coactivators. In: Wikidata. https://www.wikidata.org/wiki/Q24773704