Anatomy

Philadelphia Chromosome

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

10 entry terms
  • Ph 1 Chromosome
  • Ph1 Chromosome
  • 1 Chromosomes, Ph
  • Chromosome, Ph 1
  • Chromosome, Ph1
  • Chromosome, Philadelphia
  • Chromosomes, Ph 1
  • Chromosomes, Ph1
  • Ph 1 Chromosomes
  • Ph1 Chromosomes

MeSH Record

Aspects Covered

2 allowable subheadings

Indexed with the subheadings drug effects, radiation effects.

MeSH Record

History Note

86; was see CHROMOSOMES, HUMAN, 21-22 1978-85

MeSH Record

Previous Indexing

  • Chromosome Abnormalities (1966-1967)
  • Chromosomes (1966-1967)
  • Chromosomes, Human, 21-22 (1968-1985)
  • Leukemia, Myelocytic/FG (1966-1985)

MeSH Hierarchy

Tree Numbers

  1. A11w.284w.187w.520.300.325.345w.500w
  2. A11w.284w.187w.520.300.505.515w.500w
  3. C23.550.210w.870w.680w
  4. G05.360w.162w.520.300.325.345w.700w
  5. G05.360w.162w.520.300.505.515w.700w
  6. G05.365w.590w.175w.870w.680w

AMA Style

References

  1. National Library of Medicine. Philadelphia Chromosome. Medical Subject Headings (MeSH). 2026. Unique ID D010677. http://id.nlm.nih.gov/mesh/2026/D010677
  2. Philadelphia Chromosome. In: Wikipedia. https://en.wikipedia.org/wiki/Philadelphia_chromosome
  3. Philadelphia Chromosome. In: Wikidata. https://www.wikidata.org/wiki/Q1129111