Structured Summary
Abstract
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
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Synonyms
19 entry terms
- Bcr-Abl Tyrosine Kinase
- Fusion Proteins, bcr-abl
- bcr-abl Fusion Protein
- Bcr Abl Tyrosine Kinase
- Fusion Protein, bcr-abl
- Fusion Proteins, bcr abl
- Kinase, Bcr-Abl Tyrosine
- Protein, bcr-abl Fusion
- Tyrosine Kinase, Bcr-Abl
- bcr abl Fusion Protein
- bcr abl Fusion Proteins
- Oncogene Protein p185(bcr-abl)
- Oncogene Protein p190(bcr-abl)
- Oncogene Protein p210(bcr-abl)
- Oncogene Protein p230(bcr-abl)
- p185(bcr-abl) Fusion Proteins
- p190(bcr-abl) Fusion Proteins
- p210(bcr-abl) Fusion Proteins
- p230(bcr-abl) Fusion Proteins
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
91; was BCR-ABL FUSION PROTEINS 1990
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Previous Indexing
- Neoplasm Proteins (1986-1989)
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AMA Style
References
- National Library of Medicine. bcr-abl Fusion Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D016044. http://id.nlm.nih.gov/mesh/2026/D016044
- bcr-abl Fusion Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q72056048