Structured Summary
Abstract
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
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Synonyms
15 entry terms
- Proto-Oncogene Proteins abl
- abl Proto-Oncogene Products
- abl Proto-Oncogene Proteins
- c-abl Proteins
- Products, abl Proto-Oncogene
- Proteins abl, Proto-Oncogene
- Proto Oncogene Proteins abl
- Proto Oncogene Proteins c abl
- Proto-Oncogene Products, abl
- Proto-Oncogene Proteins, abl
- abl Proto Oncogene Products
- abl Proto Oncogene Proteins
- abl, Proto-Oncogene Proteins
- c abl Proteins
- c-abl, Proto-Oncogene Proteins
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30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
91
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Previous Indexing
- Neoplasm Proteins (1983-1985)
- Proto-Oncogene Proteins (1986-1990)
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References
- National Library of Medicine. Proto-Oncogene Proteins c-abl. Medical Subject Headings (MeSH). 2026. Unique ID D016315. http://id.nlm.nih.gov/mesh/2026/D016315
- Proto-Oncogene Proteins c-abl. In: Wikidata. https://www.wikidata.org/wiki/Q72056483