Chemicals and Drugs

Phosphofructokinase-1

An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.

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Synonyms

6 entry terms
  • 6-Phosphofructo-1-kinase
  • 6-Phosphofructokinase
  • Fructose-6-P 1-Kinase
  • Fructose-6-phosphate 1-Phosphotransferase
  • 6 Phosphofructokinase
  • Phosphofructokinase 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

general or unspecified; prefer specifics

MeSH Record

History Note

2002

MeSH Hierarchy

Tree Number

  1. D08.811w.913w.696w.620.225w.850w.500w

AMA Style

References

  1. National Library of Medicine. Phosphofructokinase-1. Medical Subject Headings (MeSH). 2026. Unique ID D010732. http://id.nlm.nih.gov/mesh/2026/D010732
  2. Phosphofructokinase-1. In: Wikipedia. https://en.wikipedia.org/wiki/Phosphofructokinase_1
  3. Phosphofructokinase-1. In: Wikidata. https://www.wikidata.org/wiki/Q427147