Chemicals and Drugs

Pimozide

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Chemical Identity

Chemical Information

Molecular Formula
C28H29F2N3O
Molecular Weight
461.5 g/mol
CAS Registry No.
2062-78-4
IUPAC Name
3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
InChIKey
YVUQSNJEYSNKRX-UHFFFAOYSA-N
SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
MeSH Unique ID
D010868
Source
PubChem CID 16362

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • Antalon
  • Orap
  • Orap forte
  • R-6238
  • R6238

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

73

MeSH Record

Previous Indexing

  • Benzimidazoles (1966-1972)
  • Tranquilizing Agents (1966-1972)

MeSH Hierarchy

Tree Number

  1. D03w.633.100.103.732w

AMA Style

References

  1. National Library of Medicine. Pimozide. Medical Subject Headings (MeSH). 2026. Unique ID D010868. http://id.nlm.nih.gov/mesh/2026/D010868
  2. Pimozide. In: Wikipedia. https://en.wikipedia.org/wiki/Pimozide
  3. Pimozide. In: Wikidata. https://www.wikidata.org/wiki/Q144085
  4. Pimozide. In: PubChem Compound. CID 16362. https://pubchem.ncbi.nlm.nih.gov/compound/16362