Chemicals and Drugs

Platelet Glycoprotein GPIb-IX Complex

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.

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Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

26 entry terms
  • Glycoprotein Ib-IX Complex
  • Glycoprotein Ib IX Complex
  • Platelet Glycoprotein GPIb IX Complex
  • Antigens, CD42a
  • Antigens, CD42b
  • Antigens, CD42c
  • Antigens, CD42d
  • CD42a Antigen
  • CD42a Antigens
  • CD42b Antigen
  • CD42b Antigens
  • CD42c Antigen
  • CD42c Antigens
  • CD42d Antigen
  • CD42d Antigens
  • Glycoprotein Ib
  • Glycoprotein Ib alpha
  • Glycoprotein Ib beta
  • Platelet Glycoprotein IX
  • Platelet Membrane Glycoprotein IX
  • Platelet Membrane Glycoprotein Ib
  • Platelet Membrane Glycoprotein V
  • Antigen, CD42a
  • Antigen, CD42b
  • Antigen, CD42c
  • Antigen, CD42d

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95

MeSH Record

Previous Indexing

  • Platelet Membrane Glycoproteins (1987-1995)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.625w.460w
  2. D12.776w.395w.550w.625w.460w
  3. D12.776w.543w.550w.625w.460w
  4. D12.776w.543w.750w.705w.675w.568w

AMA Style

References

  1. National Library of Medicine. Platelet Glycoprotein GPIb-IX Complex. Medical Subject Headings (MeSH). 2026. Unique ID D019038. http://id.nlm.nih.gov/mesh/2026/D019038
  2. Platelet Glycoprotein GPIb-IX Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Glycoprotein_Ib-IX-V_complex
  3. Platelet Glycoprotein GPIb-IX Complex. In: Wikidata. https://www.wikidata.org/wiki/Q17156451