Chemicals and Drugs

Poly(ADP-ribose) Polymerases

Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.

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Synonyms

13 entry terms
  • ADP-Ribosyltransferase (Polymerizing)
  • PARP Polymerase
  • Poly ADP Ribose Polymerase
  • Poly ADP Ribose Transferase
  • Poly ADP-Ribose Synthase
  • Poly(ADP-Ribose) Synthase
  • Poly(ADP-Ribose) Transferase
  • Poly(ADP-ribose) Polymerase
  • Poly(ADPR) Polymerase
  • Poly(ADPribose) Polymerase
  • Poly ADP Ribose Synthase
  • Polymerase, PARP
  • Synthase, Poly ADP-Ribose

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003 (1977); use NAD NUCLEOSIDASE 1975-1976

MeSH Record

Previous Indexing

  • NAD Nucleosidase (1975-1976)
  • Nucleosidases (1966-1974)

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AMA Style

References

  1. National Library of Medicine. Poly(ADP-ribose) Polymerases. Medical Subject Headings (MeSH). 2026. Unique ID D011065. http://id.nlm.nih.gov/mesh/2026/D011065
  2. Poly(ADP-ribose) Polymerases. In: Wikipedia. https://en.wikipedia.org/wiki/Poly_(ADP-ribose)_polymerase
  3. Poly(ADP-ribose) Polymerases. In: Wikidata. https://www.wikidata.org/wiki/Q3907241