Diseases

Primary Progressive Aphasia

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

9 entry terms
  • Aphasia, Primary Progressive
  • Mesulam Syndrome
  • Mesulam's Syndrome
  • Aphasias, Primary Progressive
  • Primary Progressive Aphasias
  • Progressive Aphasia, Primary
  • Progressive Aphasias, Primary
  • Syndrome, Mesulam
  • Syndrome, Mesulam's

MeSH Record

Aspects Covered

31 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, rehabilitation, surgery, therapy, urine, virology.

MeSH Record

Indexing Annotation

a clinical entity: do not confuse with descriptions of the progression of aphasia in case reports

MeSH Record

History Note

1996

MeSH Record

Previous Indexing

  • Aphasia (1982-1995)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.380w.132w
  2. C10w.597.606.150w.500w.800w.100w.155w
  3. C23.888w.592.604.150w.500w.800w.100w.155w
  4. F03w.615w.400w.125w

AMA Style

References

  1. National Library of Medicine. Primary Progressive Aphasia. Medical Subject Headings (MeSH). 2026. Unique ID D018888. http://id.nlm.nih.gov/mesh/2026/D018888
  2. Primary Progressive Aphasia. In: Wikipedia. https://en.wikipedia.org/wiki/Primary_progressive_aphasia
  3. Primary Progressive Aphasia. In: Wikidata. https://www.wikidata.org/wiki/Q18767