Structured Summary
Abstract
Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.
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Synonyms
12 entry terms
- CD230 Antigen
- Creutzfeldt-Jakob Disease Protein
- Fatal Familial Insomnia Protein
- Major Prion Protein
- PrP Proteins
- Prion Protein
- Antigen, CD230
- Creutzfeldt Jakob Disease Protein
- Prion Protein, Major
- AltPrP
- Alternative Prion Protein
- Prion Protein, Alternative
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2017: for PRION PROTEINS use PRIONS 1991-2016
MeSH Record
Previous Indexing
- Prions (2006-2016)
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AMA Style
References
- National Library of Medicine. Prion Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000072002. http://id.nlm.nih.gov/mesh/2026/D000072002
- Prion Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q24724413