Chemicals and Drugs

PrPSc Proteins

Abnormal isoform of PRION PROTEINS resulting from a posttranslational modification of the cellular prion protein (PRPC PROTEINS). PrPSc are disease-specific proteins seen in certain human and animal neurodegenerative diseases (PRION DISEASES).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Abnormal isoform of PRION PROTEINS resulting from a posttranslational modification of the cellular prion protein (PRPC PROTEINS). PrPSc are disease-specific proteins seen in certain human and animal neurodegenerative diseases (PRION DISEASES).

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Synonyms

12 entry terms
  • PrP 33-35
  • PrP-res
  • Scrapie PrP
  • Scrapie PrP 33-35
  • Sp 33-35
  • PrP res
  • HaSp 33-37
  • PrP (CJD)
  • PrP (GSS)
  • Scrapie Agent
  • Scrapie HaSp33-37 Protein
  • Scrapie Virus

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pathogenicity, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

PrPSc stands for PRion Protein SCrapie; do not confuse with PRPC PROTEINS

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History Note

95; SCRAPIE AGENT was see PRIONS 1992-94, was heading 1987-91, was SCRAPIE PRION 1986, was SCRAPIE VIRUS 1966-85; SCRAPIE PRP was NM 1988-94; SCRAPIE VIRUS was see PRIONS 1992-94, was see SCRAPIE AGENT 1987-91, was see SCRAPIE PRION 1986, was heading 1966-85; RIDA VIRUS was see SCRAPIE AGENT 1976-91

MeSH Record

Previous Indexing

  • Prions (1992-1994)
  • Viral Proteins (1989-1991)

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AMA Style

References

  1. National Library of Medicine. PrPSc Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D018620. http://id.nlm.nih.gov/mesh/2026/D018620
  2. PrPSc Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q77838387