Chemicals and Drugs

Procollagen-Proline Dioxygenase

A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.

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Classification

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MeSH Record

Synonyms

9 entry terms
  • Procollagen Prolyl 4-Hydroxylase
  • Protocollagen Prolyl Hydroxylase
  • 4-Hydroxylase, Procollagen Prolyl
  • Dioxygenase, Procollagen-Proline
  • Hydroxylase, Protocollagen Prolyl
  • Procollagen Proline Dioxygenase
  • Procollagen Prolyl 4 Hydroxylase
  • Prolyl 4-Hydroxylase, Procollagen
  • Prolyl Hydroxylase, Protocollagen

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

94; was PROLINE HYDROXYLASE 1972-93 (Prov 1972-73); PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93

MeSH Record

Previous Indexing

  • Hydroxylases (1966-1971)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.682w.690w.416w.617.750w
  2. D08.811w.682w.690w.708.694.750w

AMA Style

References

  1. National Library of Medicine. Procollagen-Proline Dioxygenase. Medical Subject Headings (MeSH). 2026. Unique ID D011393. http://id.nlm.nih.gov/mesh/2026/D011393
  2. Procollagen-Proline Dioxygenase. In: Wikipedia. https://en.wikipedia.org/wiki/Procollagen-proline_dioxygenase
  3. Procollagen-Proline Dioxygenase. In: Wikidata. https://www.wikidata.org/wiki/Q21118234