Chemicals and Drugs

Promethazine

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

Chemical Identity

Chemical Information

Molecular Formula
C17H20N2S
Molecular Weight
284.4 g/mol
CAS Registry No.
60-87-7
IUPAC Name
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
InChIKey
PWWVAXIEGOYWEE-UHFFFAOYSA-N
SMILES
CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
MeSH Unique ID
D011398
Source
PubChem CID 4927

MeSH Record

Classification

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Proazamine
  • Prometazin
  • Atosil
  • Diphergan
  • Diprazin
  • Isopromethazine
  • Phenargan
  • Phenergan
  • Phensedyl
  • Pipolfen
  • Pipolphen
  • Promet
  • Promethazine Hydrochloride
  • Prothazin
  • Pyrethia
  • Remsed
  • Rumergan
  • Hydrochloride, Promethazine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Promethazine. Medical Subject Headings (MeSH). 2026. Unique ID D011398. http://id.nlm.nih.gov/mesh/2026/D011398
  2. Promethazine. In: Wikipedia. https://en.wikipedia.org/wiki/Promethazine
  3. Promethazine. In: Wikidata. https://www.wikidata.org/wiki/Q422970
  4. Promethazine. In: PubChem Compound. CID 4927. https://pubchem.ncbi.nlm.nih.gov/compound/4927