Chemicals and Drugs

Proprotein Convertase 1

A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

18 entry terms
  • Neuroendocrine Convertase PC1
  • PC1 Endoprotease
  • PC1 Prohormone Convertase
  • PC3 Endoprotease
  • PC3 Prohormone Convertase
  • Prohormone Convertase 1
  • Prohormone Convertase 3
  • Prohormone Convertase, PC1
  • Proinsulin Convertase 1
  • Proprotein Convertase SPC3
  • Convertase 1, Proprotein
  • Convertase PC1, Neuroendocrine
  • Convertase SPC3, Proprotein
  • Convertase, PC1 Prohormone
  • Convertase, PC3 Prohormone
  • Endoprotease, PC1
  • Endoprotease, PC3
  • Prohormone Convertase, PC3

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; for PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE, PROHORMONE CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 1991-2003; for PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE use PROPROTEIN CONVERTASE (NM) 1993-2003; for PROPROTEIN CONVERTASE SPC3 use PROPROTEIN CONVERTASE (NM) 2001-2003; for PROINSULIN CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 2002-2003

MeSH Record

Previous Indexing

  • Aspartic Endopeptidases (1991-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.640w
  2. D08.811w.277w.656w.837w.500w
  3. D08.811w.277w.656w.959w.350.640w

AMA Style

References

  1. National Library of Medicine. Proprotein Convertase 1. Medical Subject Headings (MeSH). 2026. Unique ID D045664. http://id.nlm.nih.gov/mesh/2026/D045664
  2. Proprotein Convertase 1. In: Wikipedia. https://en.wikipedia.org/wiki/Proprotein_convertase_1
  3. Proprotein Convertase 1. In: Wikidata. https://www.wikidata.org/wiki/Q1668565