Chemicals and Drugs

Proprotein Convertase 5

A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN, pro-membrane type-1 matrix metalloproteinase, and NEURAL CELL ADHESION MOLECULE L1.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN, pro-membrane type-1 matrix metalloproteinase, and NEURAL CELL ADHESION MOLECULE L1.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

30 entry terms
  • Endoprotease PC6
  • PC5 Proprotein Convertase
  • PC5 Protein
  • PC6 Endoprotease
  • PC6 Protein
  • Prohormone Convertase PC-6
  • Prohormone Convertase PC5
  • Prohormone Convertase, PC5
  • Prohormone Convertase-6
  • SPC6
  • Convertase 5, Proprotein
  • Convertase PC-6, Prohormone
  • Convertase PC5, Prohormone
  • Convertase, PC5 Prohormone
  • Convertase, PC5 Proprotein
  • Convertase-6, Prohormone
  • Endoprotease, PC6
  • PC5 Prohormone Convertase
  • Prohormone Convertase 6
  • Prohormone Convertase PC 6
  • Proprotein Convertase, PC5
  • PC5A Proprotein Convertase
  • PC5B Preprotein Convertase
  • PC6A Proprotein Convertase
  • Convertase, PC5A Proprotein
  • Convertase, PC5B Preprotein
  • Convertase, PC6A Proprotein
  • Preprotein Convertase, PC5B
  • Proprotein Convertase, PC5A
  • Proprotein Convertase, PC6A

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use PREPROTEIN CONVERTASE 5 (NM) 1993-2003; for PC6 ENDOPROTEASE use PREPROTEIN CONVERTASE 5 (NM) 1993-2003

MeSH Record

Previous Indexing

  • Serine Endopeptidases (1993-2003)
  • Subtilisins (1998-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.648
  2. D08.811w.277w.656w.837w.625
  3. D08.811w.277w.656w.959w.350.648

AMA Style

References

  1. National Library of Medicine. Proprotein Convertase 5. Medical Subject Headings (MeSH). 2026. Unique ID D045702. http://id.nlm.nih.gov/mesh/2026/D045702
  2. Proprotein Convertase 5. In: Wikidata. https://www.wikidata.org/wiki/Q21154237