Structured Summary
Abstract
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
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Classification
Broader headings
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Synonyms
14 entry terms
- 20S Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Endopeptidase Complex
- Multicatalytic Proteinase
- Prosome
- Proteasome
- Complex, Multicatalytic Endopeptidase
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Multicatalytic
- Endopeptidase Complex, Proteasome
- Proteasome, 20S
- Proteinase, Multicatalytic
- Ingensin
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004
MeSH Record
Previous Indexing
- Cysteine Endopeptidases (1986-2004)
- Multienzyme Complexes (1986-2004)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Proteasome Endopeptidase Complex. Medical Subject Headings (MeSH). 2026. Unique ID D046988. http://id.nlm.nih.gov/mesh/2026/D046988
- Proteasome Endopeptidase Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex
- Proteasome Endopeptidase Complex. In: Wikidata. https://www.wikidata.org/wiki/Q13107625