Chemicals and Drugs

Ubiquitin-Protein Ligase Complexes

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

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Synonyms

3 entry terms
  • Complexes, Ubiquitin-Protein Ligase
  • Ligase Complexes, Ubiquitin-Protein
  • Ubiquitin Protein Ligase Complexes

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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Indexing Annotation

UBIQUITIN-PROTEIN LIGASES is also available

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History Note

2004

MeSH Record

Previous Indexing

  • Ligases (1983-2003)

MeSH Hierarchy

Tree Number

  1. D08.811w.464w.938

AMA Style

References

  1. National Library of Medicine. Ubiquitin-Protein Ligase Complexes. Medical Subject Headings (MeSH). 2026. Unique ID D043743. http://id.nlm.nih.gov/mesh/2026/D043743
  2. Ubiquitin-Protein Ligase Complexes. In: Wikidata. https://www.wikidata.org/wiki/Q66878287