Structured Summary
Abstract
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
MeSH Record
Classification
Broader headings
Narrower headings
- Anaphase-Promoting Complex-Cyclosome
- Autocrine Motility Factor Receptors
- Fanconi Anemia Complementation Group L Protein
- Inhibitor of Apoptosis Proteins
- Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
- Nedd4 Ubiquitin Protein Ligases
- Polycomb Repressive Complex 1
- Proto-Oncogene Proteins c-cbl
- Proto-Oncogene Proteins c-mdm2
- Seven in Absentia Proteins
- SKP Cullin F-Box Protein Ligases
- TRIM21 Protein
- Tripartite Motif-Containing Protein 28
- Tumor Necrosis Factor alpha-Induced Protein 3
- Von Hippel-Lindau Tumor Suppressor Protein
Related Concepts
Knowledge Graph
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MeSH Record
Synonyms
15 entry terms
- E3 Ligase
- E3 Ubiquitin Ligase
- Ubiquitin Ligase E3
- Ubiquitin-Protein Ligase
- Ubiquitin-Protein Ligase E3
- Ligase E3, Ubiquitin
- Ligase E3, Ubiquitin-Protein
- Ligase, E3
- Ligase, E3 Ubiquitin
- Ligase, Ubiquitin-Protein
- Ligases, Ubiquitin-Protein
- Ubiquitin Ligase, E3
- Ubiquitin Protein Ligase
- Ubiquitin Protein Ligase E3
- Ubiquitin Protein Ligases
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available
MeSH Record
History Note
2004; use UBIQUITIN-PROTEIN LIGASE (NM) 1983-2003
MeSH Record
Previous Indexing
- Ligases (1983-2003)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Ubiquitin-Protein Ligases. Medical Subject Headings (MeSH). 2026. Unique ID D044767. http://id.nlm.nih.gov/mesh/2026/D044767
- Ubiquitin-Protein Ligases. In: Wikidata. https://www.wikidata.org/wiki/Q66876434