Chemicals and Drugs

Anaphase-Promoting Complex-Cyclosome

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

MeSH Record

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MeSH Record

Synonyms

1 entry terms
  • Anaphase Promoting Complex

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • Ligases (1992-2003)
  • Ubiquitin-Protein Ligase Complexes (2004-2013)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.464w.938.750.092
  2. D12.776w.167.024

AMA Style

References

  1. National Library of Medicine. Anaphase-Promoting Complex-Cyclosome. Medical Subject Headings (MeSH). 2026. Unique ID D064173. http://id.nlm.nih.gov/mesh/2026/D064173
  2. Anaphase-Promoting Complex-Cyclosome. In: Wikidata. https://www.wikidata.org/wiki/Q77199174