Chemicals and Drugs

Nedd4 Ubiquitin Protein Ligases

E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

3 entry terms
  • Nedd4 Proteins
  • Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
  • Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1996)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.199w.500
  2. D08.811w.464w.938.750.257
  3. D12.776w.543w.990w.493w.500

AMA Style

References

  1. National Library of Medicine. Nedd4 Ubiquitin Protein Ligases. Medical Subject Headings (MeSH). 2026. Unique ID D000075702. http://id.nlm.nih.gov/mesh/2026/D000075702
  2. Nedd4 Ubiquitin Protein Ligases. In: Wikidata. https://www.wikidata.org/wiki/Q21107331