Chemicals and Drugs

Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • MALT-1 Protein
  • MALT1 Paracaspase
  • MALT1 Protein
  • Paracaspase
  • MALT 1 Protein
  • Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Paracaspase, MALT1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Caspases (1999-2017)
  • Neoplasm Proteins (1999-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.262w.500.126w.775
  2. D08.811w.277w.656w.300w.200.126w.775
  3. D08.811w.464w.938.750.233

AMA Style

References

  1. National Library of Medicine. Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000074884. http://id.nlm.nih.gov/mesh/2026/D000074884
  2. Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24743620